Category: Uncategorized
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From Vision to Innovation: The Spirit of the Taiwan Future Technology Awards
Tony Yu-Xiu Lin, Thai-Yen Ling PhD.Graduate Institute of Pharmacology, National Taiwan University College of Medicine, Taiwan Each year, the Taiwan-based “Future Technology Awards” showcase and honour pioneering technologies with the potential to transform industries, societies and lives. According to the official information for the 2025 edition, the event is part of the Future Tech Pavilion 2025 held at…
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The post-clinical trial development status of iPSC-derived platelets: Towards the application of the one-and-only universal product
Naoshi Sugimoto and Koji EtoCenter for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, Japan Preface This year marks the 200th anniversary of the first successful blood transfusions by Dr. James Blundell, saving the lives of four women with severe postpartum bleeding. Today, regenerative medicine using iPSC-derived cells is entering clinical application. In 2020,…
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Cartilage Cell–Sheet Transplantation for Osteoarthritis of the Knee: Toward a Disease‑Modifying, Joint‑Preserving Therapy
Masato SatoDepartment of Orthopaedic Surgery, School of Medicine, Tokai UniversityCenter for Musculoskeletal Innovative Research and Advancement (C-MIRA), Tokai University Graduate School Tokai University Institute of Medical Sciences Abstract Cartilage cell‑sheet engineering on temperature‑responsive culture surfaces preserves the extracellular matrix (ECM) and enables the sheet to adhere directly and uniformly to chondral defects without a scaffold.…
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Cell Sheet Engineering for Cartilage Regeneration in Japan
Junko Matsuo & Setsuko HashimotoCellSeed Inc., Tokyo, Japan Abstract Cell sheet engineering has emerged as a powerful approach for cell therapy including cartilage regeneration. We summarize the feature of cell sheet using temperature-responsive cell cultureware, and its clinical application and highlight the regulatory frameworks of regenerative medicine in Japan. We also introduce our allogeneic chondrocyte…
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Bringing Regulations into Focus at ACTO 2025
Eddie HP Tan 1, James Leong 1, Srinivasan Kellathur 1 Centre of Regulatory Excellence, Duke-NUS Medical School, National University of Singapore, Singapore2 Roche Singapore Technical Operations, Singapore ACTO 2025 in Singapore delivered 2 high-powered sessions on Day 2 of the conference, focusing on regulatory matters. In Regulatory Session 1 chaired by Dr Yoshiaki Maruyama (PMDA,…
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2025 16th ACTO Annual Meeting Report
Yunxin Chen 1, Francesca LWI Lim 1, Srinivasan Kellathur 2 & Mickey B.C. Koh 3 1 Singapore General Hospital and National Cancer Centre, Singapore2 Roche Singapore Technical Operations, Singapore 3 City St Georges, University of London, UK and St George’s University Hospital, London, UK The 16th Annual Meeting of the Asian Cellular Therapy Organization (ACTO)…
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IN MEMORIAM: PROF. CHEN
It is with heavy hearts that we announce the passing of a true hero in the fields of hematology and cell therapy, Professor Yao-Chan Chen. A pioneer, a visionary leader, and a cherished colleague, Prof. Chen left an indelible mark on the medical landscape of Taiwan and the world. Prof. Chen was not only the…
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Greetings from the editor
THE ACTO TIMES: 2025 AUTUMN EDITION Dear ACTO Members and Readers of The ACTO Times, Time flies, and it is now December 2025. This year, we have made significant advances in Asian cell and gene therapy (Asian CGT), highlighted by the great success of the 2025 ACTO Singapore Annual Meeting. However, it is with deep…
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Greetings from the ACTO chairperson
The ACTO times: 2025 Autumn edition Akihiro Shimosaka Dear ACTO members, Now we are publishing 2025 ACTO Times Autumn edition. I almost start writing the preface for this edition, just received the news, I am very sad to share this news with you regarding Prof. Yao Chan Chen who passed away on Nov. 17, 2025 in Taipei.…
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Role of Exosomes in Cancer: Molecular Mediator of Oncogenic Signaling and Microenvironmental Modulation
Mechanistic Overview of the Immune Evasion, Angiogenesis and Diagnostic Applications in Cancer Vijetha Karen Kitchley International PhD program in cell therapy and regenerative medicine, Taipei Medical University Exosomes are nano-sized extracellular vesicles (30–150 nm) encapsulated by a phospholipid bilayer and secreted by both prokaryotic and eukaryotic cells to facilitate intercellular communication and molecular signaling (Fig.…
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