Category: Uncategorized
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iPSC-derived cardiac cell sheets for heart regeneration: Progress towards clinical translation
Yuan-Yuan Cheng, Ph.D.International Ph.D. Program in Cell Therapy and Regenerative Medicine,College of Medicine, Taipei Medical University, Taiwan Abstract Background Heart disease remains the second leading cause of death worldwide. Currently, heart transplantation is considered the only definitive treatment for severe heart failure due to the poor heart regeneration after injury. Adult cardiomyocytes lose their proliferative…
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Oxidative stress-driven metabolic reprogramming failure in MERRF patient’s iPSC-derived neurons: from neurodevelopmental deficits to novel therapies
Yu-Ting Wu, Ph.D. & Yau-Huei Wei, Ph.D.Center for Mitochondrial Medicine and Free Radical ResearchChanghua Christian Hospital, Changhua City, Taiwan Abstract Background: Myoclonic epilepsy with ragged-red fibers (MERRF) syndrome is one of the severe mitochondrial encephalomyopathies, which are characterized by mitochondrial dysfunction and excess production of the reactive oxygen species (ROS). During neurogenesis, neural progenitor cells must…
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The 20-year journey of induced pluripotent stem cells (iPSCs) in regenerative medicine
Tzu-Yu Chen, Yu-Xiu Lin, & Thai-Yen Ling, Ph.D.Graduate Institute of Pharmacology, College of MedicineNational Taiwan University, Taipei, Taiwan Human induced pluripotent stem cells (iPSCs) are pluripotent stem cells generated through the reprogramming of differentiated somatic cells into an embryonic stem cell-like state via the ectopic expression of defined transcription factors. Due to their unlimited self-renewal capability…
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Discover Indonesia through ACTO Annual Meeting 2026 in Jakarta
D. Renovaldi, M.Sc.Editorial Office, The ACTO TimesInternational Ph.D Program in Medicine, Taipei Medical University, Taiwan Welcome to Indonesia Indonesia, the world’s largest archipelago, is a vibrant nation consisting of more than 17,000 islands, rich in cultural diversity, natural beauty, and warm hospitality. Home to hundreds of ethnic groups, languages, and traditions, Indonesia offers visitors a…
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17th annual meeting of ACTO will be held in Jakarta, Indonesia
“Advancing Research & Clinical Translation of Cell-Based Therapies: Academician, Business, Clinician, and Government” The 17th Annual Meeting of the Asian Cellular Therapy Organization (ACTO), in collaboration with the Indonesian Stem Cell Association (ASPI), will be held on 26–28 August 2026 in Jakarta, Indonesia. The meeting will bring together experts in cellular therapy, regenerative medicine, and…
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Japan’s Dual-Track Regulatory Framework for iPSC Therapies: Lessons, Limitations, and Global Implications
Che-Wen, Tsai, Ph.D.(Candidate.)Department of Pharmacology, College of Medicine, National Taiwan University, Taipei, Taiwan The Rise of iPS Cells: From Concept to Clinical Hope Regenerative medicine is a multidisciplinary field addressing diseases characterized by irreversible tissue loss—conditions that historically relied on organ transplantation. However, transplantation is often stymied by chronic donor shortages, ethical dilemmas, and the…
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Cell and gene therapy in Vietnam: between scientific momentum and regulatory maturation
Duy-Cuong Le, MD, Ph.D.Laboratory, Vinmec Riverside, Vinmec Healthcare System, VietnamCollege of Health Sciences, VinUniversity, Hanoi, Vietnam Introduction Cell and gene therapy (CGT) is reshaping modern medicine by enabling interventions at the level of cellular function and genetic programming. From hematologic malignancies to rare inherited disorders, these therapies have shifted from experimental promise to clinical reality…
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Current picture in cell and stem cell therapy research in Vietnam
Trang Thao Quoc Pham, MD, Ph.DGraduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, TaiwanDept. of Dermatology, Faculty of Medicine, University of Medicine & Pharmacy, Ho Chi Minh City, Vietnam Introduction In recent years, cell and gene therapy (CGT) has experienced remarkable growth in Vietnam, mirroring global innovation while leveraging local scientific expertise.…
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The university perspective in cell & gene therapy in Indonesia: landscape, challenges, progress, and a strategic vision for breakthrough
Ova Emilia, MD, Ph.D., Dian K. Nurputra, MD, Ph.D., & Rusdy Ghazali Malueka, MD, Ph.D.Univesitas Gadjah Mada, Yogyakarta, Indonesia Introduction: A Nation at the Inflection Point As the ACTO Annual Meeting 2026 convenes in Jakarta, a fitting recognition of Indonesia’s growing prominence in the Asian cellular therapy landscape, the country finds itself at a defining…
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Advancing cell-based and emerging CGT ecosystem in Indonesia: the strategic role of the Indonesian Stem Cell Association (ASPI)
Amin Soebandrio1, Rahyussalim2, Cynthia Retna Sartika1,2, Rusdy Ghazali Malueka1,2,Isabella Kurnia Liem2, Angliana Chouw2, Rima Haifa2,Retina Syhallala Askandar2, Blessari Tesalonika Woran2 1Stem Cell Committee, Ministry of Health of Indonesia, Indonesia, 2Indonesian Stem Cell Association, Indonesia Abstract Cell and gene therapy (CGT) has emerged as an important field of modern medicine, integrating regenerative medicine, stem cell science,…
