Tag: diet
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iPSC-derived cardiac cell sheets for heart regeneration: Progress towards clinical translation
Yuan-Yuan Cheng, Ph.D.International Ph.D. Program in Cell Therapy and Regenerative Medicine,College of Medicine, Taipei Medical University, Taiwan Abstract Background Heart disease remains the second leading cause of death worldwide. Currently, heart transplantation is considered the only definitive treatment for severe heart failure due to the poor heart regeneration after injury. Adult cardiomyocytes lose their proliferative…
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Oxidative stress-driven metabolic reprogramming failure in MERRF patient’s iPSC-derived neurons: from neurodevelopmental deficits to novel therapies
Yu-Ting Wu, Ph.D. & Yau-Huei Wei, Ph.D.Center for Mitochondrial Medicine and Free Radical ResearchChanghua Christian Hospital, Changhua City, Taiwan Abstract Background: Myoclonic epilepsy with ragged-red fibers (MERRF) syndrome is one of the severe mitochondrial encephalomyopathies, which are characterized by mitochondrial dysfunction and excess production of the reactive oxygen species (ROS). During neurogenesis, neural progenitor cells must…