Tag: cancer
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China’s CAR-T and Immune Cell Therapy CDMO Landscape: Process Development, GMP Manufacturing, and Platform-Based Global Expansion
Yung-Che Kuo, Ph.D.TMU Research Center for Cell Therapy and Regeneration Medicine,Taipei Medical University, Taipei, Taiwan CDMO Process Development for CAR-T and Other Immune Cell Therapy Products As chimeric antigen receptor T cell (CAR-T), universal CAR-T (UCAR-T), CAR-natural killer (CAR-NK), T cell receptor-engineered T cell (TCR-T), tumor-infiltrating lymphocyte (TIL), and other immune cell therapy products progressively…
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From First Responders to Tumor Accomplices: The Plasticity of Neutrophils in Cancer
D. Renovaldi, M.Sc.Editorial Office, The ACTO TimesInternational PhD Program in Medicine, Taipei Medical University, Taipei, Taiwan Abstract Neutrophils are traditionally portrayed as short-lived innate immune cells that rapidly migrate to sites of infection or tissue injury. Cancer, however, can appropriate these emergency-response programs for its own benefit. Tumor-derived signals alter granulopoiesis, neutrophil maturation, trafficking, lifespan, and…
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Reimagining Cancer Treatment: The 2026 Tang Prize Laureates in Biopharmaceutical Science
The ACTO Times, Editorial Office The 2026 Tang Prize in Biopharmaceutical Science has been awarded jointly to Steven A. Rosenberg, Michel Sadelain, and Carl H. June for their groundbreaking contributions to the development of cellular immunotherapy, a revolutionary approach that enables a patient’s own immune system to recognize and destroy cancer [1,2]. Established in Taiwan in…
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GREETINGS FROM THE ACTO CHAIRPERSON
The ACTO times: 2026 Summer edition Dear ACTO members and readers, It is our great pleasure to distribute ACTO Times 2026 Summer Version today. We are grateful to Prof. Huang and the ACTO Times editorial office team members who made it possible again. We are expecting the 17th ACTO Annual Meeting in Jakarta, supported by Indonesia Ministry…
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Advancing cell-based and emerging CGT ecosystem in Indonesia: the strategic role of the Indonesian Stem Cell Association (ASPI)
Amin Soebandrio1, Rahyussalim2, Cynthia Retna Sartika1,2, Rusdy Ghazali Malueka1,2,Isabella Kurnia Liem2, Angliana Chouw2, Rima Haifa2,Retina Syhallala Askandar2, Blessari Tesalonika Woran2 1Stem Cell Committee, Ministry of Health of Indonesia, Indonesia, 2Indonesian Stem Cell Association, Indonesia Abstract Cell and gene therapy (CGT) has emerged as an important field of modern medicine, integrating regenerative medicine, stem cell science,…
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Developing Gene Therapy Capacity in Thailand: Clinical, Economic, and Regulatory Perspectives
Kitipong Uaesoontrachoon1, Parin Rattananon1, Usanarat Anurathapan1,2, Suradej Hongeng11Genepeutic Bio, Co. Ltd., Bangkok, Thailand2Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand Abstract Gene therapy has emerged as a transformative therapeutic modality for genetic and hematologic diseases. In Thailand, where hemoglobinopathies and pediatric acute lymphoblastic leukemia (ALL) represent significant public health burdens, the development of domestic…
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Beyond Carcinogenesis: Connecting Nicotine Signaling with Cancer Stemness and Metastatic Progression in Triple-Negative Breast Cancer
Yung-Che Kuo, Ph.D. 1 & Yen-Hua Huang, Ph.D. 1,2,31 TMU Research Center for Cell Therapy and Regeneration Medicine, Taipei Medical University, Taipei, Taiwan.2 Department of Biochemistry and Molecular Cell Biology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan3 International Ph.D. Program in Cell Therapy and Regenerative Medicine, College of Medicine, Taipei Medical…
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Indonesia Cell & Gene Therapy (CGT) 2026 Update
Josephine Diony Nanda, M.D., Ph.D.Department of Parasitology, Faculty of Medicine, Public Health, & Nursing (FKKMK), Universitas Gadjah Mada Cell and gene therapy (CGT) has emerged as one of the most transformative innovations in modern medicine, offering new hope for patients with previously untreatable conditions. In Indonesia, the journey of CGT is still in its early…
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Role of Exosomes in Cancer: Molecular Mediator of Oncogenic Signaling and Microenvironmental Modulation
Mechanistic Overview of the Immune Evasion, Angiogenesis and Diagnostic Applications in Cancer Vijetha Karen Kitchley International PhD program in cell therapy and regenerative medicine, Taipei Medical University Exosomes are nano-sized extracellular vesicles (30–150 nm) encapsulated by a phospholipid bilayer and secreted by both prokaryotic and eukaryotic cells to facilitate intercellular communication and molecular signaling (Fig.…
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Preface 2025 ACTO Annual Congress in Singapore
It is with immense pleasure that I welcome all invited speakers, delegates and honoured guests to the 2025 Asian Cellular Therapy Organisation (ACTO) congress held in Singapore. This congress is happening at a pivotal moment in the fast-evolving field of cell and gene therapy. There are bewilderingly rapid developments in diverse areas from approved gene therapy…
