Category: Uncategorized
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Bringing Regulations into Focus at ACTO 2025
Eddie HP Tan 1, James Leong 1, Srinivasan Kellathur 1 Centre of Regulatory Excellence, Duke-NUS Medical School, National University of Singapore, Singapore2 Roche Singapore Technical Operations, Singapore ACTO 2025 in Singapore delivered 2 high-powered sessions on Day 2 of the conference, focusing on regulatory matters. In Regulatory Session 1 chaired by Dr Yoshiaki Maruyama (PMDA,…
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2025 16th ACTO Annual Meeting Report
Yunxin Chen 1, Francesca LWI Lim 1, Srinivasan Kellathur 2 & Mickey B.C. Koh 3 1 Singapore General Hospital and National Cancer Centre, Singapore2 Roche Singapore Technical Operations, Singapore 3 City St Georges, University of London, UK and St George’s University Hospital, London, UK The 16th Annual Meeting of the Asian Cellular Therapy Organization (ACTO)…
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IN MEMORIAM: PROF. CHEN
It is with heavy hearts that we announce the passing of a true hero in the fields of hematology and cell therapy, Professor Yao-Chan Chen. A pioneer, a visionary leader, and a cherished colleague, Prof. Chen left an indelible mark on the medical landscape of Taiwan and the world. Prof. Chen was not only the…
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Greetings from the editor
THE ACTO TIMES: 2025 AUTUMN EDITION Dear ACTO Members and Readers of The ACTO Times, Time flies, and it is now December 2025. This year, we have made significant advances in Asian cell and gene therapy (Asian CGT), highlighted by the great success of the 2025 ACTO Singapore Annual Meeting. However, it is with deep…
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Greetings from the ACTO chairperson
The ACTO times: 2025 Autumn edition Akihiro Shimosaka Dear ACTO members, Now we are publishing 2025 ACTO Times Autumn edition. I almost start writing the preface for this edition, just received the news, I am very sad to share this news with you regarding Prof. Yao Chan Chen who passed away on Nov. 17, 2025 in Taipei.…
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Role of Exosomes in Cancer: Molecular Mediator of Oncogenic Signaling and Microenvironmental Modulation
Mechanistic Overview of the Immune Evasion, Angiogenesis and Diagnostic Applications in Cancer Vijetha Karen Kitchley International PhD program in cell therapy and regenerative medicine, Taipei Medical University Exosomes are nano-sized extracellular vesicles (30–150 nm) encapsulated by a phospholipid bilayer and secreted by both prokaryotic and eukaryotic cells to facilitate intercellular communication and molecular signaling (Fig.…
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From Lab to Therapy: Unraveling Therapeutic Potentials of Functional Engineered Extracellular Vesicles
Joseph Wangisani Chisaka Department of Biochemistry and Molecular Cell Biology, Taipei Medical University, Taipei, Taiwan Introduction Extracellular vesicles (EVs) are emerging as powerful tools for targeted therapy of a wide range of pathologies through functional transfer of biomolecular cargoes, such as nucleic acids, lipids and proteins, to recipient cells and regulate their downstream signaling pathways…
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Harnessing the Tumor Microenvironment: Therapeutic Approaches to Modulate Cancer-Associated Fibroblasts
D Renovaldi, YH Huang.International PhD Program in Medicine, Taipei Medical University AbstractCancer-associated fibroblasts (CAFs) are key components of the tumor microenvironment (TME) and play critical roles in tumor progression, immune evasion, and therapy resistance. Their interaction with tumor cells and other stromal components reshapes the TME, supporting tumor growth and contributing to treatment failure. This…
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Preface 2025 ACTO Annual Congress in Singapore
It is with immense pleasure that I welcome all invited speakers, delegates and honoured guests to the 2025 Asian Cellular Therapy Organisation (ACTO) congress held in Singapore. This congress is happening at a pivotal moment in the fast-evolving field of cell and gene therapy. There are bewilderingly rapid developments in diverse areas from approved gene therapy…
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APSEV spotlight: illuminating the next frontier in regenerative nanomedicine
Jui-Chien Hsing Taipei Medical University, Taipei The 2025 APSEV International Conference, held in Singapore, spotlighted major breakthroughs at the frontier of regenerative nanomedicine. As a leading event in Asia devoted to extracellular vesicle (EV) research, APSEV provided key insights into how these vesicles—particularly engineered cell-derived nanovesicles (CDNs)—are transitioning from being seen as passive cellular debris…
THE ACTO TIMES 