Tag: mental-health
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Oxidative stress-driven metabolic reprogramming failure in MERRF patient’s iPSC-derived neurons: from neurodevelopmental deficits to novel therapies
Yu-Ting Wu, Ph.D. & Yau-Huei Wei, Ph.D.Center for Mitochondrial Medicine and Free Radical ResearchChanghua Christian Hospital, Changhua City, Taiwan Abstract Background: Myoclonic epilepsy with ragged-red fibers (MERRF) syndrome is one of the severe mitochondrial encephalomyopathies, which are characterized by mitochondrial dysfunction and excess production of the reactive oxygen species (ROS). During neurogenesis, neural progenitor cells must…
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Cell and gene therapy in Vietnam: between scientific momentum and regulatory maturation
Duy-Cuong Le, MD, Ph.D.Laboratory, Vinmec Riverside, Vinmec Healthcare System, VietnamCollege of Health Sciences, VinUniversity, Hanoi, Vietnam Introduction Cell and gene therapy (CGT) is reshaping modern medicine by enabling interventions at the level of cellular function and genetic programming. From hematologic malignancies to rare inherited disorders, these therapies have shifted from experimental promise to clinical reality…
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The university perspective in cell & gene therapy in Indonesia: landscape, challenges, progress, and a strategic vision for breakthrough
Ova Emilia, MD, Ph.D., Dian K. Nurputra, MD, Ph.D., & Rusdy Ghazali Malueka, MD, Ph.D.Univesitas Gadjah Mada, Yogyakarta, Indonesia Introduction: A Nation at the Inflection Point As the ACTO Annual Meeting 2026 convenes in Jakarta, a fitting recognition of Indonesia’s growing prominence in the Asian cellular therapy landscape, the country finds itself at a defining…
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Regulation of Cell and Gene Therapy (CGT) in Indonesia: Perspective of BPOM
D. Renovaldi, M.ScInternational Ph.D Program in Medicine, Taipei Medical University Introduction Cell and Gene Therapy (CGT) represents a rapidly advancing field in biomedical science, offering innovative treatment strategies for diseases that were previously difficult or impossible to treat. These therapies involve the modification or administration of living cells or genetic material to restore normal biological…
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Ushering in a new regulatory era for regenerative medicine in Taiwan
Dr. Chih-Kang Chiang, MD., Ph.D.Director-GeneralTaiwan Food and Drug AdministrationMinistry of Health and WelfareTaiwan Due to rapid development of biotechnology in recent years, the field of regenerative medicine has attracted considerable attention. Regenerative medicine related regulations have been established in several countries to ensure the quality, safety and efficacy of innovative treatments. Considering the diversity of…
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