Tag: biology
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China’s CAR-T and Immune Cell Therapy CDMO Landscape: Process Development, GMP Manufacturing, and Platform-Based Global Expansion
Yung-Che Kuo, Ph.D.TMU Research Center for Cell Therapy and Regeneration Medicine,Taipei Medical University, Taipei, Taiwan CDMO Process Development for CAR-T and Other Immune Cell Therapy Products As chimeric antigen receptor T cell (CAR-T), universal CAR-T (UCAR-T), CAR-natural killer (CAR-NK), T cell receptor-engineered T cell (TCR-T), tumor-infiltrating lymphocyte (TIL), and other immune cell therapy products progressively…
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CD19 and BCMA CAR-T Cell Therapy: A New Era in Autoimmune Disease Treatment
Vijetha Karen Kitchley, M.Sc.Editorial Office, The ACTO TimesInternational PhD Program in Cell Therapy & Regenerative Medicine, Taipei Medical University, Taipei, Taiwan Introduction Autoimmune disorders arise when immune tolerance breaks down, leading the immune system to mistakenly recognize self-tissues as foreign. These conditions collectively affect roughly 5–10% of individuals worldwide and include diseases such as systemic…
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Greeting from Editor-in Chief
THE ACTO TIMES: 2026 Summer Edition Dear Readers and Friends of The ACTO Times, It is my great pleasure to welcome you to the 2026 Summer Edition of The ACTO Times. As we enter the summer season and prepare for the upcoming 2026 ACTO-ASPI Annual Meeting, to be held on August 26–28 in Jakarta, Indonesia,…
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Therapeutic Potentials of Induced Pluripotent and Mesenchymal Stem Cell-Derived Exosomes
Vijetha Karen Kitchley, M.Sc.Editorial Office, The ACTO TimesInternational PhD Program in Cell Therapy & Regenerative Medicine, Taipei Medical University, Taiwan Introduction Mesenchymal stem cells (MSCs) have long been at the forefront of regenerative medicine due to their multipotency and immunomodulatory properties[1, 2]. However, direct stem cell transplantation is often limited by challenges such as donor-to-donor…
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The 20-year journey of induced pluripotent stem cells (iPSCs) in regenerative medicine
Tzu-Yu Chen, Yu-Xiu Lin, & Thai-Yen Ling, Ph.D.Graduate Institute of Pharmacology, College of MedicineNational Taiwan University, Taipei, Taiwan Human induced pluripotent stem cells (iPSCs) are pluripotent stem cells generated through the reprogramming of differentiated somatic cells into an embryonic stem cell-like state via the ectopic expression of defined transcription factors. Due to their unlimited self-renewal capability…
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Current picture in cell and stem cell therapy research in Vietnam
Trang Thao Quoc Pham, MD, Ph.DGraduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, TaiwanDept. of Dermatology, Faculty of Medicine, University of Medicine & Pharmacy, Ho Chi Minh City, Vietnam Introduction In recent years, cell and gene therapy (CGT) has experienced remarkable growth in Vietnam, mirroring global innovation while leveraging local scientific expertise.…
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Greeting from Editor-in Chief
THE ACTO TIMES: 2026 Spring Edition Dear readers and friends of The ACTO Times, It is my great pleasure to welcome you to the 2026 Spring Edition of The ACTO Times. As the season of renewal and growth begins, this issue offers a timely opportunity to reflect on major advances in cellular therapy and regenerative…
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Developing Gene Therapy Capacity in Thailand: Clinical, Economic, and Regulatory Perspectives
Kitipong Uaesoontrachoon1, Parin Rattananon1, Usanarat Anurathapan1,2, Suradej Hongeng11Genepeutic Bio, Co. Ltd., Bangkok, Thailand2Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand Abstract Gene therapy has emerged as a transformative therapeutic modality for genetic and hematologic diseases. In Thailand, where hemoglobinopathies and pediatric acute lymphoblastic leukemia (ALL) represent significant public health burdens, the development of domestic…
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Indonesia Cell & Gene Therapy (CGT) 2026 Update
Josephine Diony Nanda, M.D., Ph.D.Department of Parasitology, Faculty of Medicine, Public Health, & Nursing (FKKMK), Universitas Gadjah Mada Cell and gene therapy (CGT) has emerged as one of the most transformative innovations in modern medicine, offering new hope for patients with previously untreatable conditions. In Indonesia, the journey of CGT is still in its early…
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Role of Exosomes in Cancer: Molecular Mediator of Oncogenic Signaling and Microenvironmental Modulation
Mechanistic Overview of the Immune Evasion, Angiogenesis and Diagnostic Applications in Cancer Vijetha Karen Kitchley International PhD program in cell therapy and regenerative medicine, Taipei Medical University Exosomes are nano-sized extracellular vesicles (30–150 nm) encapsulated by a phospholipid bilayer and secreted by both prokaryotic and eukaryotic cells to facilitate intercellular communication and molecular signaling (Fig.…
